Journal of International Research in Medical and Pharmaceutical Sciences
 

Journal of International Research in Medical and Pharmaceutical Sciences, ISSN No. : 2395-4477 (Print), 2395-4485 (Online), Vol.: 2, Issue.: 3

Original Research Article

STUDY ON THE EFFECT OF INHALED CICLESONIDE ON SYSTEMIC INFLAMMATION IN BRONCHIAL ASTHMA

 

BALAKRISHNAN MENON1*, RAJNISH KAUSHIK1 AND CHARANJEET KAUR2
1Department of Pulmonary Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, India.
2Deaprtment of Biochemistry, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Abstracts

Introduction: The effect of Ciclesonide on systemic inflammatory and allergic markers such as C reactive protein (CRP) and IgE needs to be evaluated when given in therapeutic doses to patients of bronchial asthma.
Aims and Objectives: To evaluate effect of inhaled Ciclesonide on systemic inflammatory [CRP, Erythrocyte Sedimentation Rate (ESR)], allergic [Absolute Eosinophil Count (AEC), Sputum Eosinophil Count (SEC), IgE] in bronchial asthma.
Methods: The above parameters were assessed in 20 new patients of mild and moderate bronchial asthma who had not received inhaled or oral steroids during the past 3 months. Ciclesonide (160 mcg) was given once daily for 6weeks. All parameters were repeated at end of the study.
Results: CRP, AEC, SEC and ESR were seen to reduce significantly after treatment. Mean reduction in CRP was 2.86±0.91, p=0.011; SEC was 19.33±3.87, p=0.008, ESR was 5.35±0.79, p=0.029 and AEC was 98.95±6.24,p=0.006. IgE (202.05±15.64, p=0.060) showed non-significant reduction after treatment. FEV1 and FVC improved significantly after treatment. Mean increase in FEV1 was 0.35±0.40, p<0.01; and FVC was 0.36±0.31,p<0.01.
Conclusion: Inhaled Ciclesonide caused significant changes in systemic inflammatory parameters. Significant correlation was seen between AEC, SEC and CRP.

Keywords :

Ciclesonide, Systemic Inflammation, Bronchial asthma, CRP, IgE, Sputum Eosinophil.