Journal of International Research in Medical and Pharmaceutical Sciences
 

Journal of International Research in Medical and Pharmaceutical Sciences, ISSN No. : 2395-4477 (Print), 2395-4485 (Online), Vol.: 11, Issue.: 2

Case Report

METHEMOGLOBINEMIA, RARE BUT LETHAL SIDE EFFECT DURING CARDIAC SURGERY: A CASE REPORT

 

MAHNOOSH FOROUGHI1, MAJID GOLESTANI ERAGHI2, ALI DABBAGH3 AND MASOUD MAJIDI TEHRANI4*

1Fellowship in Cardiac Surgery, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2Chronic Respiratory Diseases Research Center, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3Fellowship in Anesthesia Cardiac Surgery, Anesthesiology Research Center, Shahid Modarres Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

4Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstracts

Methemoglobin has been developed after iron oxidation in hemoglobin. Increase in the concentration of methemoglobin causes loss of oxygen carrying capacity and cascade of aerobic oxidation impairment, metabolic acidosis and cyanosis.  Even though it is rare, it has potentially life threatening effects if neglected. Therefore, it must be recognized and corrected on time. Methemoglobinemia should be considered as one of differential diagnosis whenever low arterial oxygen saturation with preserved oxygen tension has no response to supplementary oxygen administration. In this paper, we reported a patient who developed methemoglobinemia with high dose nitroglycerin infusion during coronary artery bypass graft. He was treated with ascorbic acid.

Keywords :

Methemoglobinemia; nitroglycerin; oximetry.