Journal of Medicine and Health Research
 

Journal of Medicine and Health Research, ISSN No. : 2456-9178, Vol.: 2, Issue.: 3

Original Research Article

LIPID PROFILE IN NIGERIAN OBESE DIABETIC PATIENTS

 

EIDANGBE O. GEORGE1, IDONIJE O. BLESSING1,2*, AGBEBAKU O. SOLOMON2, MOKOGWU A. T. HUGHS3, IDEMUDIA J. OSAGIE4 AND FESTUS O. OKOJIE5

1Department of Medical Biochemistry, College of Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

2Department of Chemical Pathology, College of Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

3Department of Chemical Pathology, Faculty of Clinical Medicine, Delta State University, Nigeria.

4Department of Chemical Pathology, School of Medicine, University of Benin, Benin, Nigeria.

5Department of Medical Laboratory Science, College of Medical Sciences, Ambrose Alli University, Ekpoma, Edo State, Nigeria.

Abstracts

Background: Obesity is associated with dyslipidaemia thereby increasing the likelihood of various diseases, particularly coronary heart disease (CHD), type 2 diabetes, obstructive sleep apnea, certain type of cancers and osteoarthritis hence this study. 

Methods: This study was carried out on two hundred and two (202) subjects, aged 20-68 yrs which comprised of fifty nine (59) obese diabetic subjects and forty five (45) obese non-diabetic patients, fifty one (51) non-obese diabetic patients and sixty (60) non-obese non-diabetics (apparent healthy volunteers) as control group.  Fasting Blood Glucose (FBS, plasma lipid profile {total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), High density lipoprotein (HDL) and very low density lipoprotein (VLDL)} were estimated using standard methods.

Results: It was observed when compared that HDL and LDL in obese diabetic subjects were significantly higher than those of their control groups while the TC, TG and VLDL were not significant. LDL significantly correlated with age and BMI when obese diabetics and obese non-diabetics were compared. Mean±SD of plasma lipid profile of obese diabetic subjects on the basis of age groups and sex were not significant when compared.

Conclusion: This study confirmed that obesity and diabetes affect lipids metabolism and this abnormal lipid profile observed in this study is a proof that obesity and diabetes mellitus are associated with complications of dyslipidaemia such as coronary heart disease (CHD).

Keywords :

Obesity; diabetes mellitus; lipid profile; dyslipideamia.