Journal of Case Reports in Medical Science
 

Journal of Case Reports in Medical Science, ISSN No. : 2456-9143, Vol.: 3, Issue.: 3

Case Report

RHEUMATOID NODULE DEVELOPMENT DURING TOCILIZUMAB-INDUCED RHEUMATOID ARTHRITIS REMISSION

 

MARCO ROSSI1*, MAURO GALEAZZI2 AND STEFANIA MANGANELLI2

1Centre of Pharmacovigilance, University Hospital of Siena, Siena, Italy.

2Rheumatology Unit, University Hospital of Siena, Siena, Italy.

Abstracts

At present the effect of monoclonal antibodies on rheumatoid nodules remains poorly understood. Several cases of development or enlargement of rheumatoid nodules in association with TNF-α inhibitors have been described in the medical literature. Recently three cases of regression of rheumatoid nodules following tocilizumab have been published. We describe a 55-year-old female patient with long-standing rheumatoid arthritis, who developed an olecranon nodule during tocilizumab-induced rheumatoid arthritis remission.

Keywords :

rheumatoid nodule; tocilizumab; rheumatoid arthritis; interleukin-6.