Journal of International Research in Medical and Pharmaceutical Sciences
 

Journal of International Research in Medical and Pharmaceutical Sciences, ISSN No. : 2395-4477 (Print), 2395-4485 (Online), Vol.: 12, Issue.: 3

Original Research Article

CYTOTOXICITY TESTING OF Clitoria ternatea ON CANCER –ORIGIN CELL LINES

 

K. VALIVITTAN1 AND CHRISTINA ISAAC2*

1Department of Biotechnology, St. Peter’s University, India.

2Research Scholar, St. Peter’s University, India.

Abstracts

C. ternatea is a wellknown medicinal plant in ayurveda, its common names including blue pea, Cordofan pea, butterfly pea, and Asian pigeonwings, belongs to the family fabaceae. It was originated from tropical Asia and later was distributed widely in South and Central America, East and West Indies, China, India where it has become naturalized. The flowers of C. ternatea have been investigated for its cytotoxicity on cancer-origin cell lines such as hormone-dependent breast cancer cell line (MCF-7), Osteosarcoma cell line (MG-63) and in normal VERO cell line. The anti-proliferation activities of the extracts were demonstrated by employing colorimetric MTT (3-(4,5-dimethylthiazol-2-yl) 2,5 diphenyltetrazolium bromide) assay through time periods of 24, 48 and 72 hours. Results of this study showed that the flowers of C. ternatea had significant effects (p<0.05) against MG-63 with an IC50 value of 62.5 μg/ml and with MCF-7 as 31.2 μg/ml.

Keywords :

Clitoria ternatea; cytotoxicity; cancer cell lines.