Journal of International Research in Medical and Pharmaceutical Sciences
 

Journal of International Research in Medical and Pharmaceutical Sciences, ISSN No. : 2395-4477 (Print), 2395-4485 (Online), Vol.: 12, Issue.: 3

Original Research Article

AMELIORATING EFFECT OF Rosmarinus officinalis LEAF EXTRACT ON OXIDATIVE STRESS INDUCED IN WISTAR ALBINO RATS BY CEFTRIAXONE

 

C. N. NWADIKE1*, A. S. EZEKWE2, M. K. ANYAGWA1, O. C. ALOY-AMADI1 AND J. C. NWAOGWUGWU3

1Department of Medical Laboratory Science, Imo State University, Owerri, Nigeria.

2Department of Medical Biochemistry, Imo State University, Owerri, Nigeria.

3Department of Biochemistry, Abia State University, Uturu, Nigeria.

Abstracts

Ameliorating effect of Rosmarinus officinalis leaf extract on oxidative stress induced in Wistar albino rats by ceftriaxone using standard methods was investigated. Sixty male Wistar albino rats divided into six groups of ten rats each for normal control, experimental control and test groups (I, II, III, and IV) were used for this study. Oxidative stress was induced in the experimental control rats and test rats with the help of ceftriaxone injection. Treatment of the induced stress in rats started with oral administration of different concentrations of extract prepared from R. officinalis which lasted for twenty-eight days. Observed levels of malondialdehyde in test groups and experimental control against normal control rats revealed that oxidative stress was actually induced in rats given ceftriaxone. Levels of plasma vitamins E and C in test rats increased significantly (p<0.05) against those of the experimental control; and significantly (p<0.05) reduced against those of normal control rats. The observed effect on the studied oxidative stress indices in test rats against those of experimental control and normal control could be attributed to the ameliorating effect of R. officinalis leaf extract given orally to test rats. This study has revealed the ameliorating effect of R. officinalis leaf extract on oxidative stress induced in male Wistar albino rats by ceftriaxone.

Keywords :

Ameliorating; antioxidants; ceftriaxone; medicinal plant; oxidative stress; Rosmarinus officinalis.