Journal of Disease and Global Health
 

Journal of Disease and Global Health, ISSN No. : 2454-1842, Vol.: 11, Issue.: 2

Original Research Article

HISTOPATHOLOGICAL EFFECTS OF ATORVASTATIN IN FEMALE WISTAR RATS

 

BLESSING U. ONWUCHEKWA1*, UDOUDO M. EKANEMESANG2, EDET O. AKPANYUNG3, S. A. OYEBADEJO4  AND NSEMEKEABA GODWIN IKIDTE3

1Department of Pharmacy Technician, Abia State College of Health Sciences and Management Technology, Aba, Abia State, Nigeria.

2Department of Biochemistry, Obong University, Obong Ntak, P.O.Box 25, Abak, Akwa Ibom State, Nigeria.

3Department of Biochemistry, Faculty of Basic Medical S ciences, University of Uyo, Uyo, Nigeria.

4Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria.

Abstracts

Aim: This study was carried out to assess the possible effects of high doses of atorvastatin on the cellular profile of the liver using histopathological and histochemical techniques to evaluate the liver, heart and kidneys of female albino wistar rats.

Materials and Methods: Eighteen healthy female albino wistar rats weighing 125 to 150 g were used for this experiment. They were separated into three groups (control, therapeutic and experimental) and administered different concentrations (0, 80 and 120 mg/ml) of atorvastatin daily for 21 days. At the expiration of the treatment the animals were sacrificed. Their organs (heart, kidneys and liver) were excised and fixed in formalin solution for histological studies.

Results: The results of the study revealed mild damage to the reticular fibres and depletions of DNA of the liver.  The heart muscles did not show significant damage compared to the control.  The basement membrane of the kidneys was mildly affected. All the changes observed were dose dependent.

Conclusion: Short term exposure to atorvastatin induced a moderate damage to the liver tissues and kidney tissues, severe damage to the reticular fibres of the liver; and moderate DNA depletions in the liver of treated animals.

Keywords :

Atorvastatin; cholesterol; DNA; reticular fibres; histology.